By Radina Gigova and Amarachi Orie, CNN

01.06.25 8:44:47 AM

Dr Jose Paulo Lorenzo

Dr. Jose Paulo P. Lorenzo is a renowned rheumatologist in the Philippines, known for his expertise and leadership in the field of arthritis and autoimmune diseases. His notable roles include: Chief of the Rheumatology Section at Makati Medical Center, specializing in the treatment of arthritis, gout, lupus, and other rheumatic conditions. Consultant Rheumatologist at the Asian Hospital and Medical Center in Muntinlupa and the University of the Philippines – Philippine General Hospital (UP-PGH). President-Elect of the Asia-Pacific League of Associations for Rheumatology (APLAR). Coordinator of the Crystal-Induced Arthritis Special Interest Group (SIG) under APLAR, focusing on conditions like gout. Lead author of the 2021 APLAR Clinical Practice Guidelines for the management of gout, and a contributor to the Asia-Pacific Gout Registry Project.

Professor Jose Paulo Lorenzo has declared that he knows the key to curing joint and bone disorders—and that it is possible to eliminate these conditions at any stage.

Our reporter had the opportunity to interview this renowned doctor. Professor Jose Paulo Lorenzo explained in detail his approach to treating the root causes of these musculoskeletal illnesses. Rather than simply masking symptoms like pain or inflammation, his method focuses on regenerating cartilage, restoring joint mobility, and improving bone density—offering patients lasting relief and a true path to recovery.

Reporter: Professor Jose , you have often emphasized that cartilage regeneration is the most crucial factor in treating musculoskeletal diseases. Could you explain why this method is so foundational?

Professor Jose Paulo Lorenzo:
"Simply put, our joints—such as the knees, spine, shoulders, and hips—move smoothly thanks to a thin but extremely important layer of cartilage. This cartilage acts like a soft cushion, allowing the ends of bones to glide over each other without pain or friction.

When we’re young, cartilage is intact and rich in matrix components, keeping joints flexible and movement easy. But over time, due to factors like prolonged sitting, overexertion, lack of physical activity, or injury, this cartilage starts to wear down. Since cartilage has no direct blood supply, it has very limited ability to heal itself when damaged.

As the cartilage deteriorates, the bones begin to grind against each other, resulting in pain, inflammation, swelling, joint dryness, stiffness, and even deformities. Imagine an old door with rusty hinges—every time you open it, it creaks painfully. That’s what a joint feels like when it’s lost its protective cartilage.

That’s why, to treat conditions such as osteoarthritis, rheumatoid arthritis, spinal bone spurs, or herniated discs at their root, we must restore the cartilage. Our approach involves:

- Cleansing the blood vessels around the joint so that oxygen- and nutrient-rich blood can nourish the cartilage more effectively;

- Supplying special bioactive compounds—such as glucosamine, chondroitin, and type II collagen—to stimulate cartilage cells (chondrocytes) to regenerate cartilage matrix;

- Stabilizing the immune system and controlling inflammation to prevent further cartilage breakdown.

This isn’t just theoretical—it’s a method that has been clinically validated. Many patients who once struggled to walk and were dependent on painkillers can now move normally thanks to cartilage regeneration and joint restoration.

Think of this method like renovating a house with a rotting foundation. It’s not just about painting over the cracks (i.e., temporary pain relief), but about rebuilding the structure from the ground up to prevent the entire house from collapsing.

Only when we care for the cartilage—the root of mobility—can musculoskeletal treatment be truly effective and long-lasting."

Reporter: Professor, what serious conditions can result from damage to cartilage and joints in general?

Prof. Jose Paulo Lorenzo:
Cartilage damage is not just a simple sign of aging. When cartilage becomes worn down or inflamed, it significantly affects the entire musculoskeletal system—especially major weight-bearing joints such as the knees, hips, cervical spine, and lower back.

At first, patients may only experience mild pain during movement. But without timely intervention, the protective cartilage layer gradually thins out, leading to osteoarthritis, chronic joint inflammation, bone spurs, joint effusion, and even irreversible joint deformities.

Think of cartilage as a cushion between two bricks. Once the cushion wears away, the bricks grind against each other, causing cracks and breakage. Similarly, when joints lose their cartilage, it leads to inflammation, persistent pain, and reduced blood flow to surrounding tissues, resulting in muscle and bone weakening. Over time, this severely limits mobility and lowers quality of life.

In particular, chronic inflammation within the joint can also affect the immune system, potentially triggering systemic inflammatory responses in some cases—especially in patients with rheumatoid arthritis or lupus.

Therefore, early detection and cartilage regeneration—as soon as symptoms like joint pain, cracking sounds, or stiffness appear—are absolutely crucial. Acting early helps prevent disease progression and avoid severe long-term consequences.

To help you better understand the risks associated with musculoskeletal disorders, I’d like to share with you some images from my patients:

Joint space narrowing – caused by cartilage wear, leading to bone-on-bone contact.

Osteophyte formation (bone spurs growing around the joint) and subchondral sclerosis – late-stage signs of the disease.

Image showing ulnar deviation of the hand, with chronic swelling and joint deformity – a symmetrical pattern, typical of rheumatoid arthritis.

Gout patient

Reporter: Complications from musculoskeletal conditions such as osteoarthritis, rheumatoid arthritis, and spinal osteophytes often lead to disability and severely reduced quality of life. In the Philippines, the rate of mobility loss among the elderly due to these conditions is many times higher than in developed countries. Many experts believe that restoring cartilage and improving blood circulation around the joints are key factors in effective treatment. But why hasn't this approach been widely adopted?

Prof. Jose Paulo Lorenzo:
Yes, the situation is truly concerning. In the Philippines, most musculoskeletal patients are treated only symptomatically — with painkillers or anti-inflammatory drugs — without addressing the root cause of the disease: damaged cartilage and poor microcirculation in the joints.

Restoring cartilage and clearing the tiny blood vessels surrounding the joints are key to rebuilding a healthy joint environment. However, why isn’t this solution widely implemented? The main reason is a lack of awareness — both in the medical community and among the general public — about the critical role of cartilage and joint microcirculation. Many people still believe that joint pain is just part of aging, and that taking medication is enough. But in reality, once the cartilage is completely worn down, patients face the risk of needing joint replacement surgery, which is expensive and risky.

In Europe, cartilage regeneration combined with microvascular cleansing has been practiced for decades. People over 40 commonly start using specialized supplements to protect and nourish their cartilage. As a result, they experience fewer degenerative issues and remain physically active even into their 70s and 80s.

So the big question is: Why haven’t we made this knowledge mainstream in the Philippines? It’s a challenge of public health education. I believe that if we shift mindsets and update treatment strategies based on current scientific understanding, millions of people suffering from joint diseases can avoid surgery, break free from pain, and continue to live active, fulfilling lives.

Reporter: Let’s get straight to the point. The public is very interested in the treatment method for musculoskeletal diseases that you’ve been advocating. Could you share more about this approach?

Prof. Jose Paulo Lorenzo:
Absolutely, and I’m more than willing to share. The treatment method I’m currently using has undergone truly revolutionary changes in recent years.

In the past, when we began treating cases of osteoarthritis, arthritis, or herniated discs, the recovery process could take several months, sometimes even a year. We experimented with various natural methods—massage therapy, physical therapy, and herbal remedies—but the results were often inconsistent and required a great deal of patience and perseverance from the patient. Many people gave up halfway because they didn’t see noticeable improvements.

However, through in-depth research and serious clinical trials, we’ve discovered a new direction: combining a triad of joint-rebuilding nutrients—collagen type II, glucosamine, and chondroitin—with microcirculatory bioactive compounds. These compounds help clear the tiny blood vessels around the joints, enhancing the delivery of oxygen and nutrients to the cartilage.

Let me emphasize this: cartilage has no direct blood supply. That’s why improving circulation around the joints is the key to effective cartilage regeneration. Simply supplementing nutrients without addressing the "transport system"—the microvascular network—will lead to very limited results.

Thanks to modern biotechnology, we can now blend these nutrients into a medically standardized, easily absorbable, and user-friendly formula. And most importantly, patients can begin to feel noticeable improvement within just 2 to 4 weeks of consistent use—less pain, improved mobility, reduced swelling, and diminished joint creaking.

This is more than just symptom relief—it’s deep restoration from the root: regenerating cartilage, rebuilding joint structure, reducing inflammation, and stabilizing long-term movement. With this approach, I firmly believe that millions of people can escape the fear of chronic joint pain and disability—and return to living active, joyful, and healthy lives every day.

We named it Grandsure Max, as part of a supportive protocol for treating musculoskeletal disorders. This formula was developed based on natural herbal extracts, with the purpose of restoring and strengthening cartilage structure while enhancing blood circulation to the tissues surrounding the joints.

Unlike many synthetic pain relievers that only offer temporary symptom relief and may negatively affect the liver, kidneys, or heart, Grandsure Max works through a holistic mechanism, supporting the body comprehensively without causing side effects to vital organs.

After just 3–5 days of use, patients often report positive signs such as reduced joint pain, less morning stiffness, and a noticeable improvement in flexibility during daily movement. With regular use, it boosts the joint's natural ability to regenerate, especially in those suffering from osteoarthritis, polyarthritis, or chronic back pain.

In the Philippines, the joint restoration method using Grandsure Max has been clinically studied and applied for over a year, with official data released by the National Institute of Musculoskeletal Research.

A large-scale clinical study was conducted with 10,000 patients diagnosed with conditions such as knee osteoarthritis, polyarthritis, spinal pain, and herniated discs. All participants followed the Grandsure Max regimen as prescribed by specialists.

The results were highly promising:
- 89% of patients experienced significant relief from joint pain and stiffness within 5–7 days of use.
- 83% showed marked improvement in joint mobility and flexibility after 3 weeks.

Most importantly, no serious side effects were reported concerning liver, kidney, or cardiovascular health. These figures confirm that Grandsure Max not only supports cartilage regeneration and local blood circulation, but also represents a safe, effective, and sustainable solution for treating chronic musculoskeletal conditions—something conventional painkillers cannot offer.

This is a new direction—safe, natural, and long-lasting, helping patients regain their quality of life without having to rely on synthetic chemical pain medications.

Clinical research on Grandsure Max conducted by the Philippine Institute of Musculoskeletal Research has recorded remarkable results in the treatment of musculoskeletal conditions such as osteoarthritis, arthritis, spinal bone spurs, and sciatica:

These findings demonstrate the exceptional safety and efficacy of Grandsure Max in cartilage regeneration, chronic pain relief, and comprehensive mobility restoration, offering new hope for millions of joint patients across the Philippines and the entire Asia-Pacific region.

Reporter: “How much does Grandsure Max cost and where can people buy it?”

Dr. Jose Paulo Lorenzo:
“Currently, there are many treatment options for bone and joint diseases on the market, most of which are very expensive but deliver minimal results. However, I do not encourage the use of overpriced products.
Grandsure Max is offered at a very reasonable price, especially considering that it has become an essential part of joint disease treatment programs in the Philippines.
Furthermore, users have the opportunity to receive up to a 50% discount when purchasing the product.”

To order Grandsure Max, please fill out the official form. Your request will be automatically sent to the person in charge of the promotional program.
We will contact you after your request is submitted.